It has made no difference for me, but then I've got a CAI...
If I tried driving 60 mph out here (Mesa, AZ), I would probably get rear ended by some senior citizen (the speed limit out here is 65 mph). I usually drive ~70 mph, and I've noticed that a lot of people out here are driving slower now that the gas prices have gone up so much..Driving at 78mph will not get you good mileage, 22 sounds about right on a gt at that speed. Remember the 3g eclipses are HEAVY .. add that plus wind drag at 78 mph.. ouch :S I think you can at least get 25 tho. It all depends driving style and condition of engine. I say keep it at 60 mph and you ill see a difference, trust me. I did on my spyder(4 cyl).